In the world of in vitro fertilization (IVF), precision and control over the conditions of embryo cultivation play a crucial role in increasing the chances of a successful pregnancy. One of the most significant technological advancements in recent years in IVF laboratories is the application of Time-Lapse incubators. These incubators allow for continuous monitoring of embryo development without the need to remove them from optimal cultivation conditions, significantly improving embryo quality and, ultimately, the success of IVF.
HOW DO TIME-LAPSE INCUBATORS WORK?
Unlike traditional incubators, where embryos must be removed for assessment and monitoring of quality and developmental stages, Time-Lapse systems use built-in cameras that capture real-time images of embryos. These images are then converted into a video that embryologists can analyze without disrupting the embryonic development.
This approach eliminates the stress caused by temperature fluctuations, light exposure, and atmospheric changes with different gas concentrations, which could negatively impact the early stages of embryonic development. It also allows monitoring parameters such as cell division timing, morphological changes, and potential abnormalities.
SCIENTIFIC SIGNIFICANCE AND ADVANTAGES
Research has shown that Time-Lapse technology can increase embryo implantation success rates and reduce the risk of spontaneous miscarriages. By analyzing algorithms that evaluate the dynamics of cell division, it is possible to identify embryos with a higher implantation potential.
Key advantages of this technology include:
– Continuous monitoring of development – Reduced risk of negative effects from removing embryos from the incubator.
– Improved embryo selection – Allows for the selection of embryos with optimal development.
– Increased transparency – Patients can receive images or recordings of their embryo development, if permitted.
– Reduced embryo stress – Preservation of microenvironment stability.
ARE THERE ANY LIMITATIONS IN USE?
Although Time-Lapse incubators offer numerous advantages, their use is not without limitations. The high costs of equipment and maintenance can affect the availability of this technology in all clinics. Furthermore, there are still ongoing discussions about whether these incubators significantly increase pregnancy rates compared to standard embryo assessment methods.
CONCLUSION
The introduction of Time-Lapse technology in IVF laboratories represents a significant step towards improving the success of in vitro fertilization procedures. With the ability to continuously monitor embryos and make more precise selections, both patients and specialists gain new tools for enhancing reproductive treatments. Although there are still certain barriers regarding costs and long-term clinical effectiveness, this technology is increasingly being used and applied in clinics around the world.
REFERENCES (APA STYLE):
– Basile, N., Meseguer, M., & Palomar, C. (2015). Time-lapse technology: Evaluation of embryo development and clinical outcomes. Reproductive BioMedicine Online, 31(5), 521–532. https://doi.org/10.1016/j.rbmo.2015.08.005
– Rubio, I., Kuhlmann, R., Agerholm, I., Kirk, J., Herrero, J., Escribá, M. J., & Meseguer, M. (2014). Limited implantation success of embryos classified as having a good morphology by conventional assessment can be predicted by time-lapse imaging. Fertility and Sterility, 102(6), 1625–1633. https://doi.org/10.1016/j.fertnstert.2014.08.014
– Pribenszky, C., Nilselid, A. M., & Montag, M. (2017). Time-lapse culture with morphokinetic embryo selection improves pregnancy and live birth rates: A meta-analysis. Reproductive BioMedicine Online, 34(5), 511–520. https://doi.org/10.1016/j.rbmo.2017.02.013
– *Photo provided from Fig. 2 from Orvieto, Raoul & Shimon, Chen & Rienstein, Shlomit & Jonish-Grossman, Anat & Shani, Hagit & Aizer, Adva. (2020). Do human embryos have the ability of self- correction? Reproductive Biology and Endocrinology, 18. 10.1186/s12958-020-00650-8. licensed under CC BY 4.0 (http://creativecommons.org/licenses/by/4.0/)